From Molecule to Medicine: Onco-Innovations Aligns ONC010 for Clinical Development

Disseminated on behalf of Onco-Innovations Limited (CBOE CA: ONCO) (OTCQB: ONNVF) (Frankfurt: W1H) and may include paid advertising.

• Onco-Innovations has advanced ONC010 across API manufacturing, polymer optimization, analytical development, preclinical characterization and clinical planning as it works toward human evaluation.
• A 300-gram development batch of ONC010’s active ingredient achieved approximately 99.3% purity, while a newly identified non-tin catalyst could support improved control of impurities in future polymer manufacturing.
• The company is building an Australian pathway for a potential First-in-Human study while advancing bioanalytical, metabolism, ADME, toxicology, biodistribution and regulatory preparation during the second half of 2026.

Cancer therapies built around DNA damage face a fundamental biological obstacle: cancer cells can repair the very damage meant to destroy them. That has made DNA Damage Response (“DDR”) inhibition an important field in oncology, where the goal is to disable specific repair mechanisms and leave cancer cells more vulnerable to treatment.

Onco-Innovations Limited (CBOE CA: ONCO) (OTCQB: ONNVF) (FSE: W1H) is a preclinical-stage company pursuing an emerging target in that field, Polynucleotide Kinase Phosphatase, or PNKP. Its lead candidate, ONC010, pairs a small-molecule PNKP inhibitor with a nanoparticle delivery system. The company’s latest update brings together previously announced…

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NOTE TO INVESTORS: The latest news and updates relating to ONNVF are available in the company’s newsroom at ibn.fm/ONNVF

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