Curated News
By: NewsRamp Editorial Staff
December 15, 2025
Lionheart Health Files Patent for Bioelectric Klotho Nanoflowers to Reverse Aging
TLDR
- Lionheart Health's new patent for bioelectric-enhanced Klotho nanoflowers offers a competitive edge in longevity biotech by targeting cellular aging reversal for healthspan extension.
- The platform combines engineered nanoflowers with bioelectric stimulation to upregulate Klotho protein, restore mitochondrial function, and deliver targeted bioactive agents through precise activation sequences.
- This technology aims to improve global healthspan by reversing biological aging at the cellular level, potentially reducing age-related diseases and enhancing quality of life.
- Flower-shaped nanoparticles activated by bioelectric signals can deliver genetic payloads to mitochondria, offering a novel approach to combat aging through combined nanomedicine and bioelectric therapy.
Impact - Why it Matters
This news matters because it represents a significant advancement in the fight against aging, targeting fundamental biological processes that affect everyone. Aging is a universal concern linked to chronic diseases, cognitive decline, and reduced quality of life. By focusing on Klotho—a protein associated with longevity—and combining it with bioelectric and nanomedicine technologies, Lionheart's approach could lead to non-invasive therapies that extend healthspan, potentially reducing healthcare costs and improving well-being for aging populations globally. If successful, it could shift medical paradigms from treating age-related symptoms to addressing their root causes.
Summary
Lionheart Health, Inc., a pioneering biotechnology company specializing in bioelectric regeneration and longevity solutions, has filed a groundbreaking non-provisional U.S. patent for its innovative platform technology: Bioelectric-Enhanced Klotho Nanoflowers for Aging Reversal and Healthspan Extension. This transformative system combines flower-shaped hybrid nanoparticles with proprietary bioelectric stimulation sequences and Klotho-modulating biologics to target the cellular and mitochondrial drivers of aging. The platform integrates several of Lionheart's proprietary technologies, including BodStim™, BrainBand™, HairCell™, and advanced Klotho-based peptides and gene-expression tools, positioning the company as a global leader in healthspan technologies.
The patented nanoflowers are engineered to upregulate Klotho—a longevity-associated protein linked to improved brain, kidney, cardiovascular, and metabolic health—while restoring mitochondrial function by enhancing ATP production and reducing oxidative stress. These nanoparticles deliver targeted bioactive agents like peptides, plasmids, mRNA, and CRISPRa activators, and act as nanozyme catalysts that reduce reactive oxygen species (ROS) to improve cellular resilience. Crucially, the nanoflowers are designed to respond synergistically to Lionheart's proprietary bioelectric stimulation sequences, which increase cellular uptake, activate intracellular pathways, and amplify biological performance. According to Howard J. Leonhardt, Founder and CEO, this invention represents the convergence of three powerful emerging biotechnologies: bioelectric signaling, nanomedicine, and Klotho modulation, aiming to reverse biological age at the cellular level safely, non-invasively, and affordably.
The platform is designed for system-wide healthspan improvement, focusing on mitochondrial biogenesis, reduction of cellular senescence, and stabilization of biological age. Inspired by the future of regenerative medicine, it addresses root causes of aging like declining energy production, rising inflammation, and loss of regenerative capacity. Dr. Leslie Miller, Chief Medical Officer, highlights that this filing marks a major milestone in longevity therapeutics. Lionheart Health is preparing for expanded clinical evaluation through its network of Lionheart Longevity & Wellness Licensed Clinics and plans to integrate the technology into its XPRIZE Healthspan competition program. For more information, visit www.LionheartHealthStim.com, www.LionheartLongevity.com, and www.LeonhardtVentures.com.
Source Statement
This curated news summary relied on content disributed by Newsworthy.ai. Read the original source here, Lionheart Health Files Patent for Bioelectric Klotho Nanoflowers to Reverse Aging
