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Sethera's Enzymatic Stapler Revolutionizes Peptide Drug Design

Sethera Therapeutics unveils enzymatic platform creating stable peptide therapeutics. Breakthrough published in PNAS enables next-gen drug design with improved stability and delivery potential.

This breakthrough matters because peptide therapeutics represent a rapidly growing segment of pharmaceutical development, with applications in diabetes treatment (GLP-1 drugs like Ozempic), cancer therapies, metabolic disorders, and numerous other conditions. Traditional peptide drugs often face stability issues, poor oral bioavailability, and complex manufacturing processes. Sethera's technology addresses these fundamental challenges by creating more stable, potentially orally deliverable peptide structures through a simpler enzymatic process. This could lead to more effective treatments with better patient compliance, reduced manufacturing costs, and expanded therapeutic possibilities for conditions that currently lack optimal treatment options. The ability to work with non-natural building blocks also opens entirely new avenues for drug design that weren't previously possible.