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Helus Pharma's SPL026 Shows Promising Results in Major Depression Trial

Helus Pharma announces Phase 2a trial results showing SPL026 significantly reduces depressive symptoms in major depressive disorder patients, published in Nature Medicine.

This development represents a potential paradigm shift in mental health treatment, offering hope to millions suffering from treatment-resistant depression. Current antidepressants often take weeks to show effects and have significant side effects, leaving many patients without adequate relief. Helus Pharma's approach with novel serotonergic agonists like SPL026, which demonstrated rapid and sustained benefits with good tolerability, could transform how depression is treated. Given that depression affects over 280 million people globally and is a leading cause of disability worldwide, effective new treatments could reduce healthcare costs, improve workplace productivity, and most importantly, alleviate human suffering. The sustained effects observed up to six months suggest these treatments might offer longer-lasting relief than current options, potentially reducing the burden of chronic medication management for patients.