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Cancer Breakthrough: Zelenirstat Shows 1000x Potency as ADC Payload

Pacylex & Heidelberg Pharma reveal zelenirstat as potent ADC payload with 1000x cancer cell potency. New cancer treatment approach shows promise for breast & prostate cancers.

This collaboration represents a significant advancement in cancer treatment that could transform how we approach both hematologic and solid tumor cancers. The development of new ADC payloads is crucial because current cancer treatments often face limitations in effectiveness and side effects. Zelenirstat's novel mechanism of action targeting multiple cancer cell growth processes, combined with its demonstrated safety profile, offers hope for more effective and targeted cancer therapies. For patients facing refractory cancers with limited treatment options, this research could lead to new therapeutic alternatives that are both more potent and better tolerated. The 20 to 1000-fold increase in potency when used as an ADC payload suggests this approach could significantly improve treatment outcomes while potentially reducing side effects compared to conventional chemotherapy. As cancer remains a leading cause of death worldwide, innovations like this partnership between Pacylex and Heidelberg Pharma represent important steps forward in the ongoing battle against this devastating disease.