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NRx Pharma Expands Depression Drug Trial to Boost TMS Therapy Results

NRx Pharmaceuticals amends IND to test NRX-101 with TMS for depression. Studies show over 80% response rates, aiming to validate in a 120-patient trial.

This development matters because it addresses a critical gap in treating severe, often life-threatening depression. Current treatments, including antidepressants and therapies like TMS, don't work for everyone, leaving many patients—especially those with suicidal ideation—without effective options. The potential for NRX-101 to more than double TMS response rates could offer a lifeline to these individuals. Furthermore, by targeting neuroplasticity, this combination represents a shift toward biologically-based, mechanism-driven psychiatry. If successful, it could establish a new paradigm for treating major depressive disorder, reduce the immense personal and societal costs of treatment-resistant depression, and provide a faster, more effective path to recovery for patients who have exhausted other options.