Research Highlights:

• People who are satisfied with their lives or feel contentment or well-being may be less likely to develop heart disease and stroke than their unsatisfied counterparts.
• The analysis of health records for more than 120,000 adults in the United Kingdom found a link among people reporting the highest levels of well-being — they were less likely to develop coronary artery disease, heart attack, heart failure or have a stroke than those with lower levels of well-being.
• Researchers suggest a holistic approach to life, such as regular physical activities, social activities and/or stress management techniques, as effective ways to enhance personal well-being.

Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, Sept. 18, 2024

(NewMediaWire) - September 18, 2024 - DALLAS — People who are content with their lives or feel a sense of well-being may be less likely to develop heart disease and/or stroke compared to those with a lower sense of well-being, according to a new analysis published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

“Our findings support a holistic approach to health care, where enhancing a person’s mental and emotional well-being is considered an integral part of preventing heart disease and stroke,” said senior author Wen Sun, M.D., Ph.D., associate director of the Stroke Center at the University of Science and Technology of China in Hefei, China. “Health care professionals might consider including strategies to improve life satisfaction and happiness as part of routine care, such as recommending regular physical activities, social activities or stress management techniques as effective ways to enhance personal well-being.”

It is well-known that life satisfaction, or well-being, can increase mental health. However, the influence of well-being on cardiovascular health is less clear, the study authors wrote.

After reviewing questionnaires of more than 120,000 participants in the UK Biobank database, investigators assessed well-being as it related to satisfaction with family, friendships, health, finances and general happiness. Researchers analyzed the potential connection of well-being with the development of four major cardiovascular diseases: coronary heart disease, heart attack, heart failure and stroke. The study also examined the impact of well-being on lifestyle factors and inflammatory markers. An additional analysis, a Mendelian randomization, used genetic variations to address potential cause-and-effect questions about how modifiable risk factors may have influenced different outcomes.

The analysis found:

• Compared to adults with a low sense of well-being, the overall risk of developing cardiovascular disease was 10% to 21% lower for people with the highest well-being scores.
• Specifically, compared to adults with a low sense of well-being, people with the highest well-being scores had a 44% lower risk of coronary artery disease, 45% lower risk of stroke, a 51% lower risk of heart failure and a 56% lower risk of heart attack.
• A two-step Mendelian randomization analysis suggested that people with higher levels of well-being tended to adopt healthier lifestyles and had lower inflammatory markers. Researchers said this supports a potential cause-and-effect relationship between higher well-being and reduced cardiovascular risk.

“These results underscore the profound impact that emotional and psychological health can have on physical well-being, shedding light on intricate biological mechanisms that were not fully appreciated before,” Sun said.

A 2021 American Heart Association scientific statement, Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association, notes that psychological health can positively or negatively impact a person’s health and risk factors for heart disease and stroke.

Glenn N. Levine, M.D., a professor of medicine at Baylor College of Medicine and chair of the scientific statement, said, “While these findings are not unexpected, they add to the growing body of data that psychological health can impact cardiovascular risk.

“Much of the focus on psychological health has understandably been on negative factors such as depression and stress. This study emphasizes the importance of positive psychological health, including the more global factor of a person’s sense of well-being,” said Levine, who was not involved in the study.

Although the current study found a strong connection, there were several limitations. First, questionnaires do not always yield precise information since people may forget or answer incorrectly. Second, the study did not have information about how blood markers of inflammation may have changed over time. Finally, study participants were primarily white adults who were relatively affluent (characterized by living in less economically deprived areas, with a higher likelihood of owning property and a lower likelihood of having mortgages, shared ownership or living in rental accommodations). In addition, all participants lived in the United Kingdom, so these findings may not apply to people living in other countries.

Study details and background:

• The data reviewed was from the UK Biobank, which recruited study participants from health centers throughout the United Kingdom from 2006 to 2010.
• Participants in this analysis included 121,317 adults without heart disease when they enrolled. Their average age was 57 years old, and 45% were men.
• Over a median follow-up period of nearly 12 years, ending in October 2022, health records indicate there were 3,323 heart failure cases, 5,990 strokes, 6,462 heart attacks, and 9,177 coronary heart disease cases.
• Researchers reviewed patient questionnaires, blood tests, electronic health records and hospital procedure codes through October 31, 2022.
• In a patient survey on well-being taken at enrollment, participants rated their general happiness and satisfaction with family, friendships, health, finances and job as “Extremely happy,” “Very happy,” “Moderately happy,” “Moderately unhappy,” “Very unhappy” or “Extremely unhappy.”

Sun said future research will build on these current findings and “explore how psychological well-being might influence cardiovascular health as well as other health conditions. This line of investigation is crucial for developing a holistic understanding of how mental well-being influences overall health.”

Co-authors, disclosures and funding sources are listed in the manuscript.

Studies published in the American Heart Association’s scientific journals are peer-reviewed. The statements and conclusions in each manuscript are solely those of the study authors and do not necessarily reflect the Association’s policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Association’s overall financial information are available here.

Additional Resources:

• Multimedia is available on the right column of release link. https://newsroom.heart.org/news/happy-with-your-life?preview=da9d8decd41409ffe496e77ea182ba2a
• After Sept. 18, 2024, view the manuscript online.
• AHA news release: Depression, anxiety and stress linked to poor heart health in two new studies (Nov. 2023)
• AHA news release: Feeling loved, optimistic or happy as a teen may lead to better health in adulthood (Jan. 2023)
• AHA news release: Mental health is important to overall health, and heart disease prevention and treatment | American Heart Association (Jan. 2021)
• AHA news release: Individual psychological well-being may guard heart health in Black adults (Oct. 2020)
• AHA health information: Mental Health and Well-being
• Follow AHA/ASA news on X @HeartNews
• Follow news from the Journal of the American Heart Association @JAHA_AHA

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives. We are dedicated to ensuring equitable health in all communities. Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public’s health and share lifesaving resources. The Dallas-based organization has been a leading source of health information for a century. During 2024 - our Centennial year - we celebrate our rich 100-year history and accomplishments. As we forge ahead into our second century of bold discovery and impact, our vision is to advance health and hope for everyone, everywhere. Connect with us on heart.org, Facebook, X or by calling 1-800-AHA-USA1.

For Media Inquiries and AHA/ASA Expert Perspective: 214-706-1173

Bridgette McNeill: Bridgette.McNeill@heart.org

For Public Inquiries: 1-800-AHA-USA1 (242-8721)

heart.org and stroke.org

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