Approximately 65% of patients diagnosed with melanoma are unresponsive to immunotherapy. New research suggests that blocking the HPGDS enzyme can be a viable way to improve patients’ response to immunotherapy since the activity of this enzyme contributes to immunotherapy resistance. This approach can also increase immunotherapy response in other types of cancer with similar attributes to those of melanoma.

Given that this research was preclinical, its findings can only hold concrete promise if they are replicated in clinical studies. There’s still plenty to do before this new treatment approach can be tested on human subjects. In the meantime, immune-oncology companies like Calidi Biotherapeutics Inc. (NYSE American: CLDI) that already have new…

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