Klotho Conference Unlocks Longevity Secrets: From Gene Discovery to Healthspan Therapies

The inaugural Klotho Conference & Scientific Seminar, held at the UCI Beall Applied Innovation Center in September 2025, marked a pivotal moment in longevity research by bringing together leading scientists, clinicians, and innovators to translate decades of Klotho biology into actionable healthspan strategies. Key players included Dr. Makoto Kuroo, who discovered the Klotho gene, Menachem Abraham delivering the "State of the Industry" address, and researchers like Carmela Abraham presenting Klotho-mRNA-LNP therapeutic approaches. The conference featured presentations on diverse applications, from Dr. Assumpció Bosch's gene therapy for ALS to Dr. Gail Humble's work in medical aesthetics and Dr. Doris Taylor's vision for organ regeneration. A dedicated panel on brain health, led by Dr. Dena Dubal and Dr. Miguel Chillon, explored Klotho's neuroprotective potential, while discussions on cancer, inflammation, and muscle regeneration highlighted the protein's broad therapeutic scope. The event's agenda, accessible via the Klotho Conference website, outlined these comprehensive sessions, fostering collaborations to accelerate clinical development.

Research presented at the conference synthesized findings from over 4,390 papers published since 1997, establishing low Klotho levels as a critical biomarker linked to accelerated aging and increased risks for numerous health conditions. Evidence shows that low Klotho correlates with higher cancer risk, cognitive decline, heart and kidney failure, inflammation, muscle atrophy, and issues affecting skin, hair, bones, and sensory functions like vision and hearing. It also contributes to mitochondrial dysfunction, oxidative stress, slower wound healing, and epigenetic age acceleration, ultimately reducing healthspan and longevity. The conference emphasized that reversing these effects through elevated Klotho levels could transform aging-related healthcare, with studies underway to validate therapeutic interventions. A short highlight reel and a full playlist of presentations are available on YouTube, providing public access to these groundbreaking discussions.

The Klotho Conference catalyzed significant outcomes, including plans to accelerate clinical trials for Klotho-based gene therapies and new partnerships among academic institutions, biotech companies, and longevity investors. Organized with support from primary sponsor Lionheart Health, Inc., and linked to resources like www.lionheartlongevity.com, the event reinforced a unified mission to mainstream Klotho biology in medical strategy. Future conferences aim to expand into translational clinical trials, diagnostics development, and policy frameworks, ensuring equitable access to Klotho therapies. This landmark gathering not only advanced scientific collaboration but also set the stage for annual events that promise to drive innovation in healthy aging, making Klotho research a cornerstone of future therapeutic breakthroughs.