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Targeting DNA Repair Pathways Could Boost Cancer Immunotherapy

New study shows targeting DNA damage response pathways could make cancer immunotherapy work for more patients. Companies like Calidi Biotherapeutics explore complementary approaches.

This research matters because cancer immunotherapy has revolutionized treatment but only works for a minority of patients. By targeting DNA repair pathways that tumors use to survive, scientists may overcome one of cancer's key resistance mechanisms. This approach could potentially make immunotherapy effective for many more cancer types and patients, transforming treatment outcomes. The convergence of DDR-targeting with other approaches like oncolytic viruses represents a multi-pronged strategy that could significantly improve survival rates and quality of life for cancer patients worldwide.