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NRx Advances Safer Preservative-Free Ketamine Therapies for Depression

NRx Pharmaceuticals advances preservative-free ketamine therapies KETAFREE™ and NRX-100 through FDA regulatory pathways for depression treatment and all ketamine indications, addressing safety concerns.

This development matters because ketamine has emerged as a breakthrough treatment for severe depression and suicidal ideation, but safety concerns around preservatives like benzethonium chloride have limited its broader adoption. NRx's preservative-free formulations address critical safety issues while expanding access to this potentially life-saving treatment. For patients suffering from treatment-resistant depression and suicidal thoughts, safer ketamine options could mean reduced side effects and improved treatment outcomes. The FDA's Fast Track designation for NRX-100 underscores the urgent medical need for effective suicide prevention treatments, particularly as mental health crises continue to rise globally. This advancement also represents progress in making innovative psychiatric treatments more accessible and safer for widespread clinical use.