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Antisense Drugs Break Through: New Hope for Cancer and Pharma Economics

Antisense oligonucleotides (ASOs) are revolutionizing drug development with six new FDA approvals since 2023. Oncotelic's OT-101 leads in Phase 3 trials for pancreatic cancer, offering hope against low approval rates in oncology.

This news matters because it signals a transformative shift in drug development, where antisense oligonucleotides (ASOs) are overcoming the historically low approval rates of traditional small-molecule drugs. For patients, especially those with resistant cancers like pancreatic cancer targeted by Oncotelic's OT-101, this means faster access to potentially life-saving therapies. For the pharmaceutical industry, ASOs' rational design approach could reduce development timelines and costs, addressing long-standing economic bottlenecks. The accelerating FDA approvals—six since 2023—demonstrate growing regulatory acceptance, which may spur more investment and innovation in gene-targeted treatments, ultimately improving healthcare outcomes and expanding treatment options for underserved diseases.