Study Shows Two-Medication Combo Pill Equally Effective in Lowering Blood Pressure Among Adults in India

Research Highlights:

A study of three pills that combined two types of blood-pressure-lowering medications into one pill found that all combinations worked equally well among adults in India. Results from the TOPSPIN trial found that any two-medication combination lowered most study participants’ blood pressure to 140/90 mm Hg or less. Participants were randomly assigned to take a single pill that included either amlodipine and perindopril; perindopril and indapamide; or amlodipine and indapamide. All three treatments proved to be equally effective. The study was presented at the American Heart Association’s Scientific Sessions 2024. High blood pressure is a significant global health burden, affecting 300 million people in India and nearly half of all U.S. adults. Current international hypertension guidelines suggest combining various blood pressure-lowering medications; however, existing research has not determined which combinations offer the best outcomes in South Asian people. The study's findings have implications for South Asian adults in the U.S., as well as for simplifying medication regimens for people with hypertension.